Here we are again with another special issue of JCST devoted to using case study teaching in the science classroom. These cases are the product of the annual workshops presented by the National Center for Case Study Teaching in Science at the University at Buffalo. As part of the experience, each workshop participant develops a case and then teaches it in front of an audience of undergraduates hired for that purpose. This article describes the components of this exciting workshop, and highlights the compelling cases featured in this issue that emerged as a result.