In this chapter, the author argues that integrating science with the real and pressing concerns of human beings on this planet is a powerful way to give race, ethnicity, class, and gender a rightful place in our science classrooms. In the process, we create synergism: We draw our students into the world of science as we in turn are drawn into the world and its communities of people. As we do this, we will face intellectual challenges. To meet these challenges, we not only must ask new questions but also must keep reexamining what we ask so that we can better meet the needs of our increasingly diverse students and world.