This chapter takes you through five key lessons to putting an explore-before-explain mindset into practice using POE (Predict, Observe, and Explain) and 5E (Engage, Explore, Explain, Elaborate, and Evaluate) instructional sequences that incorporate the Next Generation Science Standards (NGSS) domains. This final chapter can help emphasize the steps necessary for supporting colleagues and developing collaborative teams interested in developing POEs and 5Es into practice while recognizing that changing one’s mindset about teaching takes time and conscious effort. Teacher background information, standards, and references are provided. This book selection also includes the Table of Contents, Foreword, Acknowledgments, About the Author, Introduction, and Index.