This chapter presents a case study on Using CRISPR to Microedit the Genome using the discovery engineering process. In this lesson, students explore the process of CRISPR, a gene-editing tool used to insert beneficial genes or delete damaging genes from DNA. Students use sample data to explore the current applications of CRISPR. They also engage in a mock town hall meeting to debate the use of CRISPR in a mosquito population control plan. Finally, students choose a global issue to tackle using CRISPR and create a grant proposal and presentation to seek funding for their idea. This lesson may be taught during a unit on genetics in biology courses. A list of materials, teacher background information, teacher notes, references, resources, assessments, and standards are provided. This book selection also includes the Table of Contents, About the Authors, Acknowledgments, Introduction, and Index.