This chapter includes activities that explore the Next Generation Science Standards (NGSS) Appendix D, “All Standards, All Students” and the case studies included with that appendix. These classroom case studies describe instructional approaches for groups of students often challenged by traditional science teaching. They are designed to illustrate how the NGSS and its three dimensions of crosscutting concepts, practices of science and engineering, and disciplinary core ideas can aid all students in the science classroom. Teacher background information, standards, and references are provided. This book selection also includes the Table of Contents, About the Authors, Contributors, A Letter from David L. Evans, Introduction, and Index.