Consider the changes. Yesterday’s one-room schoolhouse had one teacher responsible for every subject, every grade, and maintenance of the classroom and schoolhouse. Today’s self-contained classroom has one teacher responsible for a diverse group of students with wide-ranging abilities and needs; integrated learning of subjects from the basics to social and behavioral issues; and a roomful of widgets—high-tech, low-tech, and all that’s in between. Everything has changed, yet everything remains the same. You, the teacher, remain responsible for everyone and for everything that goes on in your classroom. This chapter offers some closing insights and suggestions to help you “live long and prosper” in the science classroom.