When students with limited reading, mathematical, or communication skills engage in laboratory activities, new challenges pose additional safety risks to everyone in the classroom. It’s certainly possible—and good practice—to include students of almost any ability in a program that helps all learners achieve their personal best. However, it will take some special precautions, extra organization, and the development of new sensitivities to make sure that learners of all abilities achieve their personal best in your classroom. The suggestions in this chapter won’t cover every possible barrier but they can provide your school team with a place to start.