In nanoscience, like all scientific endeavors, asking the right questions is a vital part of progress. Our ability to observe how things work at the nanoscale is very limited. We need the use of very advanced microscope technologies as well as other analysis tools to get even a hint of what is going on at this scale. As is the case in all science, the analytical and creative mind of the investigator remains the most important tool involved in the scientific process. Asking the right questions about a particular system helps us develop models of that system. In the end, our scientific understanding of the universe is a collection of models that help us make predictions. These models are constantly debated, refined, amended, and in some cases discarded as evidence and consensus dictate.