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Honeymoon Havoc

Action Potentials and Venom Pathophysiology

By Kaitlin A. Pate, Paul M. Acosta, Melinda A. Payne, Breanna N. Harris

Honeymoon Havoc


 

Abstract

In this interrupted case study, students meet a pair of fictional newlyweds on their way to Australia for their honeymoon. Initially eager to enjoy the sun, sand, and sights, Tanya and Julien Brahim end up more intimately acquainted with the local wildlife than they had planned. Tanya is bitten by a venomous arachnid and Julien has a run-in with a dangerous cnidarian. This case study was created to help students solidify their knowledge about cardiac myocytes, particularly ion movements associated with action potential generation in autorhythmic and contractile cells. As students work through the case, they complete fill-in-the-blank paragraphs describing the heart, diagram membrane potentials and ion movements, and compare and contrast action potentials from different cell types. Written for a course in human physiology, the case requires some prior knowledge of membrane potentials, equilibrium potentials, ion gradients, neuronal action potentials, and skeletal muscle action potentials. An optional pre-case assignment (included in the teaching notes) can be used to make sure that students are familiar with the necessary concepts.

   

Date Posted

11/26/2018

Overview

Objectives

  • Draw and explain the physiology of an action potential from a cardiac autorhythmic cell.
  • Draw and explain the physiology of an action potential from a cardiac contractile cell.
  • Compare and contrast the roles of sodium, potassium, and calcium in neuronal, skeletal muscle, and cardiac myocyte action potentials.
  • Describe the mechanism of action for atracotoxin and Chironex fleckeri (box jellyfish) venom.
  • Use critical thinking skills to hypothesize how atracotoxin would impact action potentials.
  • Use critical thinking skills to hypothesize how C. fleckeri venom would impact autorhythmic cell action potentials.

Keywords

Neurons; action potentials; cardiac; heart; atracotoxin; box jelly; sodium channel; venom; Australia; spider; jelly fish; cnidarian;

  

Subject Headings

Biology (General)
Medicine (General)
Natural Hazards
Nursing
Physiology
Public Health
Science (General)

EDUCATIONAL LEVEL

Undergraduate lower division, Undergraduate upper division

  

FORMAT

PDF, PowerPoint

   

TOPICAL AREAS

N/A

   

LANGUAGE

English

   

TYPE/METHODS

Interrupted

 

 

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