This analysis case study uses a jigsaw activity in which students learn about characteristics of the novel coronavirus causing COVID-19, SARS-CoV-2. The protagonist of the case, “Malik,” is a public health nurse who has been assigned to answer phone calls from the public on a COVID-19 hotline. Students use evidence-based practices and collaborative learning to help Malik answer callers’ questions and debunk common myths about the virus circulating on social media. Each question is assigned to a small working group of students who read academic sources about SARS-CoV-2 and become experts on their topic; students then reassemble into new groups and share their knowledge with others who were assigned a different question. By the end of the activity, students will have learned about SARS-CoV-2 origins, transmission, epidemiology, pathogenicity and treatment and about the importance of evidence-based practices in public health. This case was designed for undergraduate and graduate courses of various levels related to microbiology, virology, epidemiology and general biology but could be adapted for upper-level and AP high school and two-year college courses.