The Sisters in Sport Science (SISS) program addresses the need for girls to gain equitable access to science and mathematics education by using sport as a vehicle for learning. Through sport, not only are girls learning the underlying principles of science and mathematics embedded in the mechanics of performing a sport; but also, they are learning the scientific principles in an atmosphere that embraces their psycho-social-emotional connection to learning. This article provides an overview of this standards-based program and describes an activity relating track and field to physical science.