In this directed case study, a six-month-old infant, “Henry,” is brought to the ER with significant gastrointestinal bleeding. An emergency physician relies on the appearance of Henry’s stool, bowel sounds, and various imaging techniques to reach a diagnosis of Meckel’s diverticulum. Students draw on their knowledge of gastrointestinal anatomy and physiology to explain Henry’s clinical signs and explore how ectopic gastric mucosa can trigger severe hemorrhage. Designed for a two-semester anatomy and physiology (A&P) course taken by nursing, nutrition, athletic training, pre-occupational therapy, and other health-related majors in their first or second year, the case could also be adapted for advanced high school A&P students.