Skip to main content
 

Death Becomes Us

Apoptosis and Carcinogenesis

By Michele M. Cox

Death Becomes Us


 

Abstract

This interrupted case study reviews the cellular and molecular mechanisms involved in apoptosis, or programmed cell death, and how it may be used in the treatment of cancer. The case narrative follows "Derek," a college student who travels to Philadelphia for a summer internship at a biotech company. During his internship, Derek learns about apoptosis, the types of cellular pathways involved, and the various components in those pathways. Students are asked to think critically and apply information learned in the case study to answer questions and create hypotheses. The questions are suitable for upper-level undergraduate students in cellular or molecular biology. Before attempting the case, students should have a basic understanding of cell/molecular biology and the cell division/cell cycle. A PowerPoint presentation containing the crucial figures from the case study handout is included so that instructors can project these visuals in the classroom as needed to guide student understanding and discussion.

   

Date Posted

12/03/2018

Overview

Objectives

  • Define cancer.
  • Describe the difference between malignant and benign tumors.
  • Describe the difference between necrosis and apoptosis.
  • Describe the two major classes of apoptotic caspase, initiator caspase and executioner caspase, and their functions.
  • Explain the extrinsic and intrinsic pathways.
  • Describe the executioner phase of apoptosis and the morphology of an apoptotic cell.
  • Explain how these pathways are regulated by c-FLIP, Bcl2 family proteins and IAPs.
  • Explain how defects to the apoptotic mechanisms can possibly lead to cancer.
  • Hypothesize how targeting defects to the apoptotic mechanisms can possibly lead to treatments for cancer.

Keywords

Apoptosis; programmed cell death; cancer; caspase; Bcl2;

  

Subject Headings

Biology (General)
Cell Biology
Microbiology
Molecular Biology

EDUCATIONAL LEVEL

Undergraduate upper division, Graduate

  

FORMAT

PDF, PowerPoint

   

TOPICAL AREAS

N/A

   

LANGUAGE

English

   

TYPE/METHODS

Interrupted

 

 

Asset 2