Undergraduate students are often unaware that early modern humans originated in Africa and that over many millennia many populations of humans walked thousands of miles across the Earth to become all the indigenous populations we see today. This case study includes simulations designed to demonstrate how human migration occurred over the last 100,000 years and how these ancient migrations can be studied by comparing DNA sequences from modern humans. In the simulations, students model these migrations physically by migrating around a large map of the world that is drawn on the floor. Completing this activity helps students develop a clearer appreciation for human origins and a greater understanding of the methods used by scientists to determine migration patterns. The case is designed for advanced high school (AP) or introductory college courses of biology, anthropology, social studies, history, or any other course that focuses on race or ethnicity.