In this intimate debate case, students consider whether to support the development and use of Golden Rice as a means to alleviate vitamin A deficiency in the developing world. Since many of the arguments typically raised against genetically modified organisms (GMOs) do not apply to this particular GM crop, students are forced to analyze the facts rather than rely on what they have heard in the media. Teams of students are presented with evidence that supports either the pro or con position. Based on this information, they formulate arguments to defend their position, then present their case to another team. Each team also listens to arguments from a team defending the other position. Listening skills are developed in addition to scientific argumentation skills, since in the next phase of the debate students must defend the opposite position. This is followed by a whole-class discussion that explores broader issues and questions introduced by the case.  Developed for an introductory molecular biology undergraduate course, the case could also be used at more advanced levels.