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I Hate Running!

And Lactate Is to Blame, Right?

By Ashley E. Rhodes, Timothy G. Rozell, Abigail R. Wilson

I Hate Running!


 

Abstract

This interrupted worksheet case study, developed for introductory or intermediate undergraduate physiology courses, aims to eliminate misconceptions that many students have about lactate, lactic acid, and changes in the body during exercise. The case begins with two fictional undergraduate students discussing the causes of muscle soreness; both of these characters have obvious misunderstandings about this issue that are likely to be shared by many students. As the case develops, students are presented with information in a variety of forms including flow charts and work through some of the chemical reactions that take place in actively contracting skeletal muscle cells to better understand the real cause of muscle soreness. By the end of the case, students will have explored this complex issue from multiple angles.

   

Date Posted

11/16/2018

Overview

Objectives

  • Distinguish between lactic acid and lactate including production in skeletal muscle.
  • Explain why lactate is a useful compound for skeletal muscle cells.
  • Describe why skeletal muscle cells produce different LDH isoforms and that LDH is a protein thus created via transcription and translation.
  • Describe lactate elimination from the muscle cell producing it and the value of symporters for facilitated diffusion.
  • Clarify H+ production and elimination in muscle cells, and why lactate is not a cause of proton production (acidification) and muscle soreness.
  • Relate how misuse of correlations has allowed faulty information to be propagated for decades.

Keywords

Exercise; lactate; lactic acid; muscle physiology; metabolism; aerobic respiration; anaerobic respiration

  

Subject Headings

Biology (General)
Cell Biology
Physiology
Sports Science

EDUCATIONAL LEVEL

Undergraduate lower division, Undergraduate upper division

  

FORMAT

PDF

   

TOPICAL AREAS

History of science

   

LANGUAGE

English

   

TYPE/METHODS

Interrupted

 

 

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