In this problem-based learning (PBL) case study, a college student experiencing severe abdominal pain and vaginal bleeding is shocked to learn that she is suffering a miscarriage. Student teams embark on the iterative process of identifying learning issues and conducting research to find the necessary information to not only assess the probable cause(s) of her miscarriage, but also make recommendations as to how to prevent both unplanned pregnancies and miscarriages in the future. Originally designed for a lower-level undergraduate course in human anatomy, the case can easily be adapted for any course in anatomy and physiology, embryology, or developmental biology, or any other course that covers the reproductive system or early embryonic development.  It is designed to take less than three class hours, but can easily be expanded or contracted according to the learning goals of the instructor.