This case study describes the medical journey of a nurse whose eventual diagnosis of Ehlers-Danlos syndrome (EDS) was years in the making. EDS is difficult to diagnose because of its variety of symptoms that overlap with other conditions. Chronic pain, fatigue, and joint instability are widespread and affect many different areas of the body.  When a patient seeks medical intervention for EDS, it is not uncommon for them to receive multiple incorrect diagnoses. As a result, individuals can endure years of pain beset with unnecessary medical tests and treatments. This case study gives students an opportunity to explore a variety of topics related to EDS (e.g., structure and function of intervertebral joints, epidural injections, collagen, inheritance patterns, supportive care). Originally designed for undergraduate students in the first semester of an anatomy and physiology two-semester sequence, the case can easily be adapted for non-science majors in a human biology course. Before beginning the case, students should have a good understanding of the various connective tissues of the human body and the characteristics of joints.