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New Tricks for Old Drugs

Using High-Throughput Screening to Repurpose Medications

By Carlos C. Goller, Stefanie H. Chen, Melissa C. Srougi

New Tricks for Old Drugs


 

Abstract

This case study is designed to raise awareness of the use of high-throughput screening (HTS), the resources available at PubChem, and the potential for discovery of promising therapeutics in collections of existing drugs. Students prepare for the case by viewing several background videos. Once in class, they access a published and highly cited HTS screen for small molecules to stop Zika virus epidemics, and then interact directly with the data in PubChem to dissect the research findings. The case can be extended to consider how similar approaches and PubChem database searches can be used in the search for drugs to combat the novel coronavirus responsible for the COVID-19 pandemic. The case is ideally suited for upper-division undergraduate students or graduate students (e.g., first year or professional students in pharmacy or medicine) in a molecular biology or medicinal chemistry course with enough time for class work in groups and productive discussions.

   

Date Posted

09/27/2021

Overview

Objectives

  • Summarize the objective(s) of a published high-throughput screen (HTS).
  • Explain the experimental approach used for HTS in this study.
  • Identify lead compounds from a HTS published in PubChem and their known activities.
  • Analyze the IC50 data from a published figure.
  • Execute a PubChem search to find active compounds against other diseases.
  • Reflect on the significance of HTS such as this one.

Keywords

High-throughput screening; HTS; Zika; PubChem; compounds; inhibition; drug discovery; drug development

  

Subject Headings

Bioinformatics
Epidemiology
Microbiology
Science (General)

EDUCATIONAL LEVEL

Undergraduate upper division, Graduate

  

FORMAT

PDF

   

TOPICAL AREAS

N/A

   

LANGUAGE

English

   

TYPE/METHODS

N/A, Flipped, Journal Article

 

 

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