This set of “mini cases” focuses on autoimmune diseases, which arise when the immune system is unable to recognize its own components. Students are presented with two patients, “Claudia” and “Anita,” who are introduced through the use of two short videos. Acting in the role of immunologists, students are then assigned to teams and given one of the patient cases to explore in detail, integrating fundamental immunology concepts with laboratory tests to develop a diagnosis and course of treatment for their patient. The two patient scenarios can be easily updated as new guidelines and treatments are described. These mini cases are appropriate for junior or senior undergraduates or first year graduate students in the healthcare profession.