In many physiology classes the frog neuromuscular junction (NMJ) is presented as the classic example of a chemical synapse, but many synapses show properties that are different. For example, in many chemical synapses there is a protein transporter in the presynaptic membrane that is responsible for the uptake of liberated neurotransmitter from the synaptic cleft. Certain drugs can interfere with the function of these transporters and therefore can change the level of neurotransmitter in the cleft. This interrupted case study tells the story of one student who takes a prescription drug to control depression and a second student who takes amphetamines to act as a stimulant and maintain his ability to concentrate. The two drugs affect the pre-synaptic reuptake transporter for different neurotransmitters. This case was written for a one-semester animal physiology course taken by sophomore and junior science majors; it could also be used in a general biology course that covers the function of chemical synapses.