A systems approach to science education is one of the powerful interdisciplinary ideas that AAAS recommends be woven through science learning at all levels and in all content areas. AAAS also calls for making systems thinking explicit in middle school and suggests that students investigate biological, electrical, and mechanical systems to determine how they work by identifying their parts and the connections and effects these parts have, not only on each other, but on the entire system as well. To that end—this month’s issue is devoted to incorporating a systems approach to science teaching. Here the Editor highlights the articles related to this interdisciplinary theme.