Due to his work to determine how cholera was spread in the 18th century, John Snow (1813-1858) has been hailed as the father of modern epidemiology. This article presents an inquiry model based on his life and work, which teachers can use to develop a series of biology lessons involving the history and nature of science. The lessons presented use a combination of literature, history, critical thinking, and simulation to promote “the use of history in school science programs to clarify different aspects of scientific inquiry, the human aspects of science, and the role that science has played in the development of various cultures” as recommended by the National Science Education Standards (NRC 1996, p. 107).