At the age of 35, “Mary Joe’s” once healthy life is changed permanently as she experiences symptoms which begin to hinder her quality of life. Confused and concerned, she seeks out medical advice and is subsequently diagnosed with relapsing remitting multiple sclerosis (RRMS), an autoimmune neurodegenerative disorder characterized by degradation of the neuronal myelin sheath in the central nervous system.  In this case study, students are guided through Mary Joe’s journey to a medical diagnosis and subsequent experiences living with RRMS.  Students are tasked with thinking critically about the physiological and social implications of living with a chronic neurodegenerative disorder including risk factors, symptomology, diagnostic testing, and clinical reasoning. Emphasis is given to the role of social determinants of health (SDH), and students are challenged to consider how one’s unique social factors contribute to healthcare access, disease prognosis, and overall well-being. The case is suitable for use in a variety of upper-level undergraduate courses such as human anatomy and physiology, neuroscience, physiology, pathophysiology, and immunology.