In this case study, students meet “Callie” and “Nate,” who are expecting their first child. During the pregnancy, their baby is diagnosed with a congenital heart defect known as transposition of the great arteries (TGA). As students learn about TGA, they gain an understanding of the difference between adult and fetal cardiac anatomy and circulation. Specifics such as sites of gas exchange, oxygenation status, and post-birth structural changes are covered. In addition to discussing the pathology, diagnosis, correction, and prognosis of TGA, optional sections explore the topics of empowering patients and showing empathy. This interrupted case study is designed for undergraduate anatomy and physiology students and nursing students. The teaching notes have suggestions for modifying the case for a high school audience. The case can be completed in one 90-minute class period, although alternative timing suggestions are provided for 55- and 75-minute classes.