This case study describes the fictional experiences of “Maria,” a person recently diagnosed with metastatic cancer and prescribed the drug methotrexate. In the story, Maria discusses her treatment plan with her doctor and learns about her medication. Students apply their knowledge of cell biology to explain how Maria’s cancer became metastatic and the molecular basis of methotrexate chemotherapy, which targets cells that are dividing at a faster rate than others. They research Maria’s treatment and learn about the pioneering contributions of Dr. Jane Wright Cook, an African American woman, to cancer research. Finally, they discuss the impact that race and gender could have on a biomedical scientist, particularly one working in the United States in the mid-1900s. This case study was designed for an introductory biology course and could also be used for AP Biology courses.