Based on a real incident, this case features an older woman who has been injured on a ski slope. Her classic knee injury, often referred to as the “Terrible Triad of O’Donahue,” is complicated by her age, the altitude, and possible hypothermia. In a stepwise fashion, students are introduced to the evaluation of the injury, structure of the knee joint, complicating factors, treatment of the injury, rehabilitation, and the patient’s eventual recovery. The topic of the case is often of particular interest to college-aged student-athletes, many of whom have faced a similar injury. Developed for students in the first semester of a two-semester anatomy and physiology course, the case could be adapted for a human biology course.