This case study explores the structure and function of the integumentary system through the lens of a severe acne case. Using detailed images, a patient narrative, and an interactive dialogue between a dermatologist and patient, students gain a realistic, empathetic, and comprehensive perspective on acne. Students label key skin structures on an image and explore the stages of acne development and the inflammatory process. In addition, the role of Cutibacterium acnes bacteria in acne formation is examined, alongside discussions about the importance of responsible antibiotic use. Finally, the case study introduces isotretinoin as a treatment option and addresses common myths and misconceptions surrounding acne. This holistic approach not only enhances anatomical and physiological knowledge about the integumentary system but also explores some of the psychological impacts of acne. Originally designed for pre-medical students studying anatomy and physiology, the case is also suitable for a range of learners, including introductory health science students. It can also be used in pathophysiology courses.