Recent educational initiatives call for changes in science education that promote the development of students’ scientific skills, such as interpreting data, applying concepts, and synthesizing information. Although these initiatives do not explicitly recommend that primary literature should be incorporated as a component of undergraduate science education, instruction with primary literature can promote these skills. This chapter reviews the importance of students interacting with primary literature, where to locate primary literature that supports course content, how to determine which articles to include, and multiple approaches for integrating scientific literature into courses.