Active learning is a teaching methodology with a focus on student-centered learning that engages students in the educational process. This study implemented active learning techniques in an orthopedic assessment laboratory, and the effects of these teaching techniques. Mean scores from written exams, practical exams, and final course evaluations were compared for 79 human physiology students. One- and two-way analyses of variance were used to evaluate the effect of teaching methodology on test scores and evaluation responses. No significant differences were found for course evaluation responses and written and practical exam scores between the two learning groups. This study suggests that students can be equally successful in well-constructed active and traditional orthopedic assessment laboratories.