Skip to main content
 

The Ebola Wars: Advanced Edition

By Derek Dube, Linda M. Iadarola, Tracie M. Addy

The Ebola Wars: Advanced Edition


 

Abstract

This case study was written for upper level undergraduate and graduate students to review foundational aspects of virology and to examine Ebola virus infection in detail. Terry is a college student who travels to a West African clinic for the summer as a volunteer. While abroad, Terry comes into contact with a patient infected with the Ebola virus and later displays the signs and symptoms of an Ebola virus infection. Terry then learns about the general features of viruses and viral life cycles, as well as the most up to date information about features unique to the Ebola virus, the host cell response to Ebola virus infection, and treatment options. Students are expected to have a basic knowledge of cell biology, the central dogma, and viral life cycles.  Students are asked to think critically and apply information learned in the case to answer questions, create hypotheses, and design appropriate biological experiments. A more general version of the case, suitable for a general biology course, is also available on this site.

   

Date Posted

02/09/2016

Overview

Objectives

  • Explain the general features of viruses (structure and life cycle).
  • Describe major structural features of the Ebola virus.
  • Devise a therapeutic strategy that targets the Ebola virus to prevent infection.
  • Describe the mechanisms by which the Ebola virus enters and leaves the host cell, including the roles of the host cell and Ebola virus factors.
  • Describe the arrangement of the Ebola virus genome and how it plays a role in protein production and virus particle assembly.
  • Design an experiment to test the impact of a non-functional Ebola viral protein on the viral life cycle.
  • Devise a strategy to inhibit Ebola virus from exiting the cell.
  • Describe major therapies available.
  • Describe how the outbreak of the Ebola virus speaks to the nature of science and scientific discovery.

Keywords

Viruses; Ebola virus; Ebola therapy; viral structure; infection; viral life cycle; disease; viral entry; host restriction factors; capsid; glycoproteins; immunotherapy; ZMapp

  

Subject Headings

Biology (General)
Cell Biology
Medicine (General)
Microbiology
Molecular Biology

EDUCATIONAL LEVEL

Undergraduate upper division, Graduate

  

FORMAT

PDF, PowerPoint

   

TOPICAL AREAS

N/A

   

LANGUAGE

English

   

TYPE/METHODS

Directed, Interrupted

 

 

Asset 2