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Favorite Demonstration: Demonstrating Enzyme Activation—Calcium/Calmodulin Activation of Phosphodiesterase

Journal of College Science Teaching—November/December 2004

This exercise provides a simple method to visually demonstrate the third step in the calcium/calmodulin signal transduction pathway, that is, the activation of a target protein phosphodiesterase without the use of radioactivity. Using hands-on methods allows students to understand and remember the concepts involved and the importance of these pathways in coordination of cellular activities.
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