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Favorite Demonstration: The Effect of Calcium on the Binding of Calmodulin to Calcium/Calmodulin Protein Kinase II: Demonstrating the Calcium-Dependent Binding of Calmodulin to a Target Protein

Journal of College Science Teaching—December 1999/January 2000

This exercise visually demonstrates that the binding of calcium to calmodulin changes its conformation to allow binding to a target protein, calcium/calmodulin protein kinase II. It introduces undergraduates to the concept of regulatory pathways controlled by second messengers by illustrating the important role of calmodulin in the mediation of calcium signal transduction pathways.
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