This chapter discusses the key components of two contemporary sequences of science instruction. You will read about the phases of the Predict, Observe, and Explain (POE) and 5E instructional models. The activity boxes included are aimed at helping you reflect on hands-on practices you currently use and how they may be sequenced to promote even higher levels of learning. Teacher background information, safety notes, standards, and assessments are provided. This book selection also includes the Table of Contents, Foreword, Acknowledgments, About the Author, Preface, Introduction, References, and Index.