This chapter discusses the key components of two contemporary sequences of science instruction. It presents the phases of the POE (Predict, Observe, and Explain) and 5E (Engage, Explore, Explain, Elaborate, and Evaluate) Instructional Models. The activity boxes are aimed at helping you reflect on hands-on practices currently used and how they may be sequenced to promote even higher levels of learning. Teacher background information, standards, and references are provided. This book selection also includes the Table of Contents, Foreword, Acknowledgments, About the Author, Introduction, and Index.