This chapter provides guidance on how you can create 5Es that translate the Next Generation Science Standards (NGSS). Activities are presented following each factor that you should consider when planning 5Es and offer some planning ideas to design “explore-before-explain” instructional sequences based on cognitive science research. The activity boxes included are meant to provide a professional development experience and promote job-embedded learning. Teacher background information, safety notes, standards, and assessments are provided. This book selection also includes the Table of Contents, Foreword, Acknowledgments, About the Author, Preface, Introduction, References, and Index.