This chapter presents a case study on Controlling Mosquitoes to Stem Malaria Infection using the discovery engineering process. In the lesson, students learn how scientists discovered the way in which malaria spreads. Students review malaria infection data and reported cases and then create a plan that outlines a means to help reduce or eliminate malaria transmission and infections. This lesson may be taught during a unit on bacterial characteristics, infectious disease, transmission of disease, or epidemiology. A list of materials, teacher background information, teacher notes, references, resources, assessments, and standards are provided. This book selection also includes the Table of Contents, About the Authors, Acknowledgments, Introduction, and Index.