This chapter presents a case study on The Discovery of Dangerous Drug Interactions using the discovery engineering process. In this lesson, students read a case study on the discovery of the adverse effect of combining grapefruit with certain medicines. Playing the role of a medical scientist, they then use sample data to investigate an adverse reaction connected to a food or drink interaction. Last, they develop an application for a known food or drink drug interaction that solves a problem. This lesson may be taught during a unit on chemical reactions or human biology. A list of materials, teacher background information, teacher notes, references, resources, assessments, and standards are provided. This book selection also includes the Table of Contents, About the Authors, Acknowledgments, Introduction, and Index.